Emergent deployment of extracorporeal membrane oxygenation (ECMO) has revolutionized the world of resuscitation. Historically, survival from refractory cardiac arrest was dismal, but now extracorporeal cardiopulmonary resuscitation (ECPR) can be used to provide a bridge to return of spontaneous circulation. Effective incorporation of resuscitative ECMO requires a novel procedural skillset, swift operational organization and interprofessional team collaboration. This book, written by experts in the field, serves as a practical guide for implementing resuscitative ECMO.