effect of menstrual cycle on the pharmacokinetics of drugs

effect of menstrual cycle on the pharmacokinetics of drugs

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The aim was to monitor carefully follicular growth arrest in
polycystic ovaries by assay of hormones in individual follicles.
DESIGN AND PATIENTS: Fluid from follicles less than or equal to 10 mm was
obtained from ovaries of 16 regularly cycling women between days 1 and 12 of the
follicular phase (controls, n = 120 follicles), polycystic ovaries of five women
with polycystic ovary syndrome (n = 43), and polycystic ovaries from 14 long-term
testosterone treated female to male transsexuals (n = 120).
MEASUREMENTS: Fluid was assayed for oestradiol, androstenedione