This is the fourth book in a series of depressing comic books. Sunday Depresso is about 2 guys being depressed on Sundays because they have to go to work the next day. You only see them on Sundays.
This book is magical realism-flavored, and the 2 guys are Jesus and Chief Running Dog, who originally met in 33AD shortly after Jesus's resurrection and became best friends.
I suppose you could say this book answers the age-old question, "what would Jesus do?" I mean, it answers it in the sense of...what would Jesus do if He lived in this time period? Apparently, the answer is, "Get depressed, drink beer, and smoke a lot of pot."